Police officers Linda and Mary investigate a series of gruesome murders involving dogs while a mysterious, rapidly mutating virus begins to spread through the city. As the contagion causes victims to become violent and erratic, their friend Kata becomes infected, leading to a chaotic confrontation that leaves Linda herself falling victim to the contagion.
As monstrous creatures—formerly humans—terrorize the city, Mustang arrives to warn that Kata is trapped in a terrible nightmare. While the police attempt to save the transformed victims using special talismans, a sadistic Colonel views the chaos as a game and launches missiles into Central Park where the monsters have gathered. Amidst the madness of a viral evolution, Mary and Kata must be awakened from their primal delusions before the military's destructive whims claim more lives.