Desperate to win over the school's most beautiful girl, Saginomiya Megumi, Hajime Mukaiyama uses a mysterious aphrodisiac drug called HoreKime provided by his friend Misa. The drug triggers an intense, uncontrollable desire in Megumi, leading to a passionate encounter between the two in the school's science preparation room after Hajime finally confesses his love.
After Hajime and Megumi solidify their romantic bond, Misa's hidden feelings for Hajime are brought to the surface through the use of a potent love drug called the HoreKime pill. Overcome by the drug's effects, Misa confesses her deep love for Hajime, leading him to accept both women and engage in a passionate encounter that further complicates their romantic triangle.