In a mysterious clinical facility known as the Special Ward, Nakamura-sensei conducts clandestine experiments using potent drugs to manipulate human biology and desire. Targeting the ward's nurses, the doctor administers an experimental aphrodisiac to Shinohara and Hitomi, leading to intense sexual encounters and unexpected physiological mutations. As the boundaries of gender and anatomy blur under the influence of the medication, the doctor's hidden biological secrets are revealed through a series of erotic trials.
Makimura-sensei continues her clandestine experiments using specialized medication to alter the anatomy and inhibitions of the ward's nurses. When a strict colleague attempts to report her for using unlicensed drugs, she is instead drugged and forced to succumb to her own hidden desires. The experiment further expands to include the Naruse sisters, as the sensei pushes her subjects toward total submission and pregnancy to awaken their primal instincts.