After a shipwreck leaves a group of students stranded on a mysterious island, the surviving girls are afflicted by a virus that causes uncontrollable sexual arousal and potential heart failure. Shouta discovers that his semen is the only known cure, forcing him to engage in sexual experiments with his classmates to save their lives and study the virus.
Months after the shipwreck, Shouta has established himself as the absolute authority over the virus-infected survivors. As he continues to dominate the girls and their teacher, he uncovers that Dr. Ichijou orchestrated the outbreak as a scientific experiment. By using the concentrated virus to break the doctor's will, Shouta ensures the total submission of every woman on the island.